This collection houses records related to Dr. Sophie Trent's medical career, particularly her education and subsequent research on tropical diseases, and dates from 1924 to 1989. While Trent seems to have led quite a distinguished medical career, this collection focuses on the time just after her graduation from Yale medical school, when she researched and treated patients afflicted with tropical disease. The collection is divided into six series: "I. School records," "II. Research and writing files," "III. Professional Associations," "IV. Personal papers," "V. Microscope slides," and "VI. Medical books and other publications."

The series "I. School records, 1940-1949" houses several medical school notebooks, as well as draft and final copies of Trent's thesis. At the end of the series are three miscellaneous publications related to her time at Pembroke and Yale.

"II. Subject/Research and Writing files, 1944-1963" includes files related to Trent's research and writings on tropical diseases. In particular, researchers will find manuscript and published versions of Trent's writings, general information, case histories and photographs of microscope slides used in Trent's research. The files in this series are organized alphabetically by subject, which is typically the name of a disease or parasite.

"III. Professional Associations, 1948-1985" houses ephemera of various women's medical associations, or which Trent was a member. The files are organized alphabetically by organization name.

"IV. Personal papers, 1939-1987" includes a random assortment of biographical information about Trent, especially related to her appointments at various hospitals and other professional history, and newspaper clippings about her paintings. The files are arranged chronologically.

"V. Microscope slides, undated" includes two boxes of pathology slides from Trent's research on Tropical Diseases.

The last series, "VI. Medical books and other publications, 1924-1983" houses a random sample of publications related to Trent's education, hospital work, as well as three published volumes of Trent's poetry.